Organometallic Compounds
Medchemexpress LLC DBCO-S-S-PEG3-biotin | 1430408-09-5 | 96.9% | 869.12 | 25 MG
DBCO-S-S-PEG3-biotin is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. It functions as a click chemistry reagent, possessing a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing azide groups.
- PEG-based PROTAC linker
- Click chemistry reagent
- Contains a DBCO group for SPAAC reactions
- Used in the synthesis of PROTACs
Medchemexpress LLC 5,8,11-Trioxa-2-azatetradecanedioic acid, 1-(4-cycloocten-1-yl) ester | 2141981-86-2 | MFCD31811538 | 96.0% | 373.44 | 25 MG
TCO-PEG3-acid is a click chemistry reagent that contains a TCO group, which can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups. It is also a click chemistry PEG linker with a terminal carboxylic acid group. The terminal carboxylic acid is reactive with primary amine groups in the presence of activators to form a stable amide bond.
- Contains a TCO group for inverse electron demand Diels-Alder reaction (iEDDA)
- Reacts with molecules containing Tetrazine groups
- Functions as a click chemistry PEG linker
- Terminal carboxylic acid group
- Forms stable amide bonds with primary amine groups in the presence of activators
Medchemexpress LLC NH2-PEG3-C6-Cl | 1261350-60-0 | 95.0% | 267.79 | 100 MG
NH2-PEG3-C6-Cl is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs (Proteolysis Targeting Chimeras) contain two different ligands connected by a linker; one for an E3 ubiquitin ligase and the other for the target protein. These molecules exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Facilitates selective protein degradation
- For research use only
Medchemexpress LLC N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid | 2183440-74-4 | 98.1% | C29H55N5O13 | 25 MG
N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent.
- Can participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules.
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Utilized in the synthesis of PROTACs.
- Enables selective degradation of target proteins through the intracellular ubiquitin-proteasome system.
Medchemexpress LLC Bromoacetamido-PEG3-azide | 940005-81-2 | ≥97.0% | C10H19BrN4O4 | 25 MG
Bromoacetamido-PEG3-azide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent due to its Azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Alkyne groups. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent with an azide group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne groups
- Engages in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups
- Facilitates selective degradation of target proteins through the intracellular ubiquitin-proteasome system
- Intended for research use only
Medchemexpress LLC N-(Boc-PEG3)-N-bis(PEG2-alcohol) | 2055042-60-7 | > 96.0% | C25H52N2O11 | 100 MG
N-(Boc-PEG3)-N-bis(PEG2-alcohol) is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. These PROTACs consist of two distinct ligands connected by a linker, where one ligand targets an E3 ubiquitin ligase and the other targets a specific protein.
- Composed of two distinct ligands connected by a linker.
- One ligand targets an E3 ubiquitin ligase and the other targets a specific protein.
- Leverages the intracellular ubiquitin-proteasome system.
- Achieves selective degradation of target proteins.
Medchemexpress LLC Aminooxy-PEG3-C2-NH-Boc | 2062663-65-2 | C13H28N2O6 | 1 G
Aminooxy-PEG3-C2-NH-Boc is a PEG- and Alkyl/ether-based PROTAC linker designed for the synthesis of PROTACs. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting a ligand for an E3 ubiquitin ligase with a ligand for the target protein.
- Suitable for PROTAC synthesis
- Molecular weight: 308.37
- Targeted for PROTAC linkers pathway
- Recommended storage: 4°C, sealed, away from moisture and light (solid); -80°C for 6 months or -20°C for 1 month (in solvent)
Medchemexpress LLC Aminooxy-PEG3-C2-NH-Boc | 2062663-65-2 | C13H28N2O6 | 5 G
Aminooxy-PEG3-C2-NH-Boc is a PROTAC linker, specifically a PEG- and Alkyl/ether-based linker, utilized in the synthesis of PROTACs. PROTACs (Proteolysis Targeting Chimeras) are designed to exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. They function by connecting two different ligands: one that binds to an E3 ubiquitin ligase and another that targets a specific protein.
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Connects a ligand for an E3 ubiquitin ligase to a target protein
- Facilitates selective degradation of target proteins
Medchemexpress LLC N-(acid-PEG3)-N-bis(PEG3-azide) | 2182602-17-9 | 98.1% | C25H49N7O11 | 100 MG
N-(acid-PEG3)-N-bis(PEG3-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Azide group that can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker for PROTAC synthesis
- Click chemistry reagent with an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with alkyne groups
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups
Medchemexpress LLC Atorvastatin-PEG3-FITC | 1440755-31-6 | 98.2% | C64H68FN5O12S | 10MG
Atorvastatin-PEG3-FITC is a fluorescently labeled derivative of atorvastatin used as a ligand in fluorescence anisotropy assays and reported as a KRAS-PDEδ interaction inhibitor (compound S31). It is provided for research use with defined chemical characteristics and high reported purity suitable for biochemical experiments.
- Acts as a ligand in fluorescence anisotropy assays.
- Reported to inhibit KRAS-PDEδ interaction (compound S31).
- Contains an FITC fluorescent tag for fluorescence-based detection.
- High reported purity (98.17%) suitable for biochemical assays.
- Defined molecular formula and molecular weight for assay calculations.
- Available in small research pack sizes for assay optimization.
Medchemexpress LLC Nh2-peg5-c6-cl hydrochloride | 2241669-16-7 | 98.0% | 5 G
NH2-PEG5-C6-Cl hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC THP-PEG3-OH | 60221-37-6 | 98.7% | 5 G
THP-PEG3-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- Can be used in the synthesis of PROTACs
- Contains two different ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Azido-PEG5-alcohol | 86770-68-5 | MFCD20134131 | >97.0% | 263.29 g/mol | C10H21N3O5 | 250 MG
Azido-PEG5-alcohol is a 5-unit polyethylene glycol (PEG) linker bearing an azide and a terminal hydroxyl group, used as a click-chemistry reagent and as a non-cleavable PEG spacer in conjugation and PROTAC synthesis. Purity is ≥97.0%, molecular weight is 263.29 g/mol, and CAS number is 86770-68-5.
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions.
- Compatible with strain-promoted azide-alkyne cycloaddition (SPAAC) with DBCO or BCN.
- Non-cleavable 5-unit PEG spacer to improve solubility and flexibility.
- Available in multiple sizes, including 250 mg.
- High purity suitable for synthetic and conjugation applications.
Medchemexpress LLC Azido-PEG3-SS-PEG3-azide | 1310827-27-0 | 99.3% | C16H32N6O6S2 | 10MG
Azido-PEG3-SS-PEG3-azide is a symmetric, cleavable polyethylene glycol (PEG)-based bifunctional linker bearing terminal azide groups and a central disulfide bond. It is designed for bioconjugation and PROTAC synthesis, enabling both copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC), while allowing reductive cleavage for controlled release.
Medchemexpress LLC Mal-PEG3-NH2 TFA | 2830214-77-0 | 99.1% | 386.32 g/mol | C14H21F3N2O7 | 50 MG
Mal-PEG3-NH2 TFA is a linear, heterobifunctional polyethylene glycol (PEG) crosslinker supplied as the trifluoroacetic acid (TFA) salt. It contains a maleimide at one end and a primary amine at the other, enabling thiol-to-amine conjugation and use as a non-cleavable linker in PROTAC and bioconjugation workflows. For research use only.
- Provides maleimide and primary amine reactive groups for orthogonal conjugation.
- PEG3 spacer improves aqueous solubility and reduces steric hindrance.
- TFA salt form enhances stability and handling compared with the free base.
- Non-cleavable linker suitable for stable conjugates and PROTAC constructs.
- High purity (>99%) for consistent conjugation performance.